Cross-Species Immunity Following Immunization With a Circumsporozoite Protein–Based Vaccine for Malaria

Antitumor Immunity Induced by Genetic Immunization with Chitosan Nanoparticle Formulated Adjuvanted for HPV-16 E7 DNA Vaccine

Protective Immunity in Mice Following Immunization with the Cochleate-Based Subunit Influenza Vaccines

High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...

Cross-species malaria immunity induced by chemically attenuated parasites.

Vaccine development for the blood stages of malaria has focused on the induction of antibodies to parasite surface antigens, most of which are highly polymorphic. An alternate strategy has evolved from observations that low-density infections can induce antibody-independent immunity to different strains. To test this strategy, we treated parasitized red blood cells from the rodent parasite Plas...

Cross-species immunity in malaria vaccine development: two, three, or even four for the price of one?

Cross-Species Immunity in Malaria Vaccine Development: Two, Three, or Even Four for the Price of One? Bruno Douradinha,† Maria M. Mota, Adrian J. F. Luty,* and Robert W. Sauerwein Department of Medical Microbiology, University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; Unidade Malaria, Instituto de Medicina Molecular, Universidade de Lisboa, 1649-028 Lisboa, Portugal; and...

Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.

Immunization with irradiated sporozoites protects animals and humans against malaria, and the circumsporozoite protein is a target of this protective immunity. We now report that adjuvant-free intramuscular injection of mice with plasmid DNA encoding the Plasmodium yoelii circumsporozoite protein induced higher levels of antibodies and cytotoxic T lymphocytes against the P. yoelii circumsporozo...